Biotecnología

Biotecnología

Free Radical Lipid Peroxidation Induced by Reactive Halogen Species
11/03/2024 - Abstract The review is devoted to the mechanisms of free radical lipid peroxidation (LPO) initiated by reactive halogen species (RHS) produced in mammals, including humans,...
Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome
11/03/2024 - Abstract Down syndrome (DS) arises from a genetic anomaly characterized by an extra copy of chromosome 21 (exCh21). Despite high incidence of congenital diseases among DS...
Transfer of membrane(s) matter(s)—non-genetic inheritance of (metabolic) phenotypes?
11/03/2024 - Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer phospholipid layer of eukaryotic plasma membranes exclusively by a glycolipid. GPI-APs are not only released into...
YB-1 Targeted by miR-509-3-5p Affects Migration and Invasion of Triple?Negative Breast Cancer by Regulating Cellular Epithelial?Mesenchymal Transition
11/03/2024 - Abstract The epithelial–mesenchymal transition (EMT) process is closely linked to metastasis of breast cancer. This article elucidates the role of Y-box binding protein-1 (YB-1)...
Degrade to stay healthy—Proteolytic interplay during inflammation
11/03/2024 - Proteasomes and autophagy constitute the 2 main proteolytic machineries for cytoplasmic content. A new study in PLOS Biology now demonstrates that autophagy stimulation alters proteasome composition,...
Discrimination ability of central visual field testing using stimulus size I, II, and III and relationship between VF findings and macular ganglion cell thickness in chiasmal compression
11/03/2024 - Purpose To compare the relationship between macular ganglion cell layer (mGCL) thickness and 10–2 visual field (VF) sensitivity using different stimulus sizes in patients with temporal...
Network analysis of spread of SARS-CoV-2 within dialysis clinics: A multi-center network analysis
11/03/2024 - Background In-center hemodialysis entails repeated interactions between patients and clinic staff, potentially facilitating the spread of COVID-19. We examined if in-center hemodialysis is...
Microbial production of dextran using pineapple waste extract: a two-step statistical optimization of submerged fermentation conditions and structural characterization
11/03/2024 - Abstract A two-step optimization protocol was attempted to optimize the condition for dextran production from pineapple waste using Leuconostoc mesenteroides NCIM-2198. Response...
Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof
11/03/2024 - The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19 infections in early diagnosed patients. The main...
Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function
11/03/2024 - Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure....
Circ_0082374 Promotes the Tumorigenesis and Suppresses Ferroptosis in Non-small Cell Lung Cancer by Up-Regulating GPX4 Through Sequestering miR-491-5p
11/03/2024 - Abstract Circular RNAs (circRNAs) have been identified to be dysregulated in non-small cell lung cancer (NSCLC) and implicated in the progression of this cancer. Here, this work...
Role for gene conversion in the evolution of cell-surface antigens of the malaria parasite <i>Plasmodium falciparum</i>
11/03/2024 - While the malaria parasite Plasmodium falciparum has low average genome-wide diversity levels, likely due to its recent introduction from a gorilla-infecting ancestor (approximately 10,000 to...
Short video platforms as sources of health information about cervical cancer: A content and quality analysis
11/03/2024 - Background The development of short popular science video platforms helps people obtain health information, but no research has evaluated the information characteristics and quality of short...
Evaluation of variability in performance and paw placement patterns by dogs completing the dog walk obstacle in an agility competition
11/03/2024 - The objective of this study was to describe paw placement patterns for canine athletes completing the dog walk obstacle during canine agility trials. It was hypothesized that dogs would demonstrate...
Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication
11/03/2024 - Abstract Introduction The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator...
Voltammetric analysis of pholcodine on graphene-modified GNPs/PTs with green assessment
11/03/2024 - Pholcodine, an anti-tussive medication widely used as an over-the-counter, OTC drug, has recently faced restrictions in several countries. This paper presents a sensitive electrochemical approach for...
A GC–MS-based untargeted metabolomics approach for comprehensive metabolic profiling of mycophenolate mofetil-induced toxicity in mice
11/03/2024 - Background: Mycophenolate mofetil (MMF), the morpholinoethyl ester of mycophenolic acid, is widely used for maintenance immunosuppression in transplantation. The gastrointestinal toxicity of MMF...
Photonic chip-based low-noise microwave oscillator
11/03/2024 - Nature, Published online: 06 March 2024; doi:10.1038/s41586-024-07140-6Global profiling of hyper-reactive...
FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid–liquid phase separation
11/03/2024 - Proteome analyses of the postsynaptic density (PSD), a proteinaceous specialization beneath the postsynaptic membrane of excitatory synapses, have identified several thousands of proteins. While...
Photoimmuno-antimicrobial therapy for <i>Staphylococcus aureus</i> implant infection
11/03/2024 - Introduction Implant infections caused by Staphylococcus aureus are responsible for high mortality and morbidity worldwide. Treatment of these infections can be difficult especially when...
Changes in functioning and health during the first 6-months of the COVID-19 pandemic among individuals with a spinal cord injury
11/03/2024 - Study design Single-cohort longitudinal survey design. Objectives To identify what ongoing impact the COVID-19 pandemic has on functioning and health in individuals with SCI. Using the ICF...