Biotecnología
Biotecnología
Enhanced resistance to heat and fungal infection in transgenic Trichoderma via over-expressing the HSP70 gene
16/04/2024 -
Heat stress is one of the major abiotic stresses affecting the growth, sporulation, colonization and survival of Trichoderma viride. This study aimed to gain a better insight into the underlying...
The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane
16/04/2024 -
Abstract Ionic liquids (ILs) are organic salts with a low melting point. This is due to the fact that their alkyl side chains, which are covalently connected to the ion,...
Erratum to: Viral Vectors in Gene Replacement Therapy
16/04/2024 -
In this article the funding section was misprinted unintentionally. The funding statement should be corrected as follows: A.D.E. was supported by the Russian Science...
Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer’s disease management; in vitro and in silico study
16/04/2024 -
In this article, we present the design and synthesis of amino-7,8-dihydro-4H-chromenone derivatives as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the...
The Mechanism of Inhibition of Mycobacterial (p)ppGpp Synthetases by a Synthetic Analog of Erogorgiaene
16/04/2024 -
Abstract The synthesis of (p)ppGpp alarmones plays a vital role in the regulation of metabolism suppression, growth rate control, virulence, bacterial persistence, and biofilm...
Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models
16/04/2024 -
Cancer is a deadly illness with a convoluted pathogenesis. The most prevalent restrictions that frequently result in treatment failure for cancer chemotherapy include lack of selectivity,...
Association of Increased Homocysteine Levels with Impaired Folate Metabolism and Vitamin B Deficiency in Early-Onset Multiple Sclerosis
16/04/2024 -
Abstract The contents of homocysteine (HCy), cyanocobalamin (vitamin B12), folic acid (vitamin B9), and pyridoxine (vitamin B6) were analyzed and the genotypes of the main...
Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4?,3?:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors
16/04/2024 -
The starting compound 3-amino-1,7-dihydro-4H-pyrazolo[4,3-c]pyridine-4,6(5H)-dione (1) is reacted with each of diketone and ?-ketoester, forming pyridopyrazolo[1,5-a]pyrimidines 4a,b and 14a,b,...
Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data
16/04/2024 -
Abstract Some tricyclic antidepressants (TCAs), including amitriptyline (ATL), clomipramine (CLO), and desipramine (DES), are known to be effective for management of...
Integrative analysis of proteomics and lipidomic profiles reveal the fat deposition and meat quality in Duroc × Guangdong small spotted pig
16/04/2024 -
IntroductionThis study aims to explore the important factors affecting the characteristics of different parts of pork.MethodsLipidomics and proteomics methods were used to analyze DAL (differential...
Novel Gain-of-Function Mutation in the Kv11.1 Channel Found in the Patient with Brugada Syndrome and Mild QTc Shortening
16/04/2024 -
Abstract Brugada syndrome (BrS) is an inherited disease characterized by right precordial ST-segment elevation in the right precordial leads on electrocardiograms (ECG), and...
Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation
16/04/2024 -
Abstract Ferroptosis is a unique form of cell death reliant on iron and lipid peroxidation. It disrupts redox balance, causing cell death by damaging the plasma membrane, with...
Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration
16/04/2024 -
Abstract Structural organization of HIV-1 integrase is based on a tetramer formed by two protein dimers. Within this tetramer, the catalytic domain of one subunit of the first...
Recombinant Amidases: Recent Insights and its Applications in the Production of Industrially Important Fine Chemicals
16/04/2024 -
Abstract The current research for the synthesis of industrially important fine chemicals is more inclined towards developing enzyme-based processes. The biotransformation...
Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway
16/04/2024 -
Abstract Platelets are known for their indispensable role in hemostasis and thrombosis. However, alteration in platelet function due to oxidative stress is known to mediate...
Modeling locomotion from environment to neurons
16/04/2024 -
Nature Methods, Published online: 12 April 2024; doi:10.1038/s41592-024-02251-4Modeling locomotion from...
Human Blood Serum Counteracts EGFR/HER2-Targeted Drug Lapatinib Impact on Squamous Carcinoma SK-BR-3 Cell Growth and Gene Expression
16/04/2024 -
Abstract Lapatinib is a targeted therapeutic inhibiting HER2 and EGFR proteins. It is used for the therapy of HER2-positive breast cancer, although not all the patients...
Noninvasive in vivo microscopy of single neutrophils in the mouse brain via NIR-II fluorescent nanomaterials
16/04/2024 -
https://www.nature.com/articles/s41596-024-00983-3 Nature Protocols, Published online: 11 April 2024;
Protective Activity of Inactivated Rabies Vaccine Using Flagellin-Based Adjuvant
16/04/2024 -
Abstract Rabies is a zoonotic disease with high lethality. Most human deaths are associated with the bites received from dogs and cats. Vaccination is the most effective...
Control of DNA replication in vitro using a reversible replication barrier
16/04/2024 -
https://www.nature.com/articles/s41596-024-00977-1 Nature Protocols, Published online: 09 April 2024;
Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies
16/04/2024 -
Abstract Less than ten years ago, evidence began to accumulate about association between the changes in the composition of gut microbiota and development of human...
