Biotecnología

Biotecnología

The Jatropha leaf curl Gujarat virus on infection in Jatropha regulates the sugar and tricarboxylic acid cycle metabolic pathways
19/09/2022 - Abstract Jatropha, a popular biodiesel crop, suffers severe losses due to Jatropha leaf curl Gujarat virus (JLCuGV) infection in Gujarat (India). Metabolite profiling can help...
Implication of non-coding RNA-mediated ROCK1 regulation in various diseases
19/09/2022 - Rho Associated Coiled-Coil Containing Protein Kinase 1 (ROCK1) is a protein serine/threonine kinase which is activated upon binding with the GTP-bound form of Rho. This protein can modulate...
Impact of diurnal temperature range on hospital admissions for cerebrovascular disease among farmers in Northwest China
19/09/2022 - Scientific Reports, Published online: 13 September 2022; doi:10.1038/s41598-022-19507-8Impact of diurnal...
Genomic and evolutionary characteristics of G9P[8], the dominant group a rotavirus in China (2016–2018)
19/09/2022 - G9P[8] became the predominant rotavirus A (RVA) genotype in China in 2012. To evaluate its genetic composition at the whole-genome level, 115 G9P[8] RVA strains isolated from children under 5...
Orphan drug development in alpha-1 antitypsin deficiency
19/09/2022 - Scientific Reports, Published online: 15 September 2022; doi:10.1038/s41598-022-19707-2Orphan drug development...
The Role of Endoplasmic Reticulum Stress in Differentiation of Cells of Mesenchymal Origin
19/09/2022 - Abstract Endoplasmic reticulum (ER) is a multifunctional membrane-enclosed organelle. One of the major ER functions is cotranslational transport and processing of secretory,...
Perilipin-2 limits remyelination by preventing lipid droplet degradation
19/09/2022 - Abstract Foamy macrophages and microglia containing lipid droplets (LDs) are a pathological hallmark of demyelinating disorders affecting the central nervous system (CNS). We...
Genomic characterization of a new phage BUCT541 against Klebsiella pneumoniae K1-ST23 and efficacy assessment in mouse and Galleria mellonella larvae
19/09/2022 - Over the past decades, the spread of multi-drug-resistant Klebsiella pneumoniae (MDR-KP) is becoming a new threat and new effective therapies against this pathogen are needed. Bacteriophage...
Knockdown of Krüppel-Like Factor 9 Inhibits Aberrant Retinal Angiogenesis and Mitigates Proliferative Diabetic Retinopathy
19/09/2022 - Abstract Advanced proliferative diabetic retinopathy (PDR) characterized by aberrant retinal angiogenesis is a leading cause of retinal detachment and blindness. Krüppel-like...
Insights to the superoxide dismutase genes and its roles in Hevea brasiliensis under abiotic stress
19/09/2022 - Abstract The superoxide dismutase (SOD) protein significantly influences the development and growth of plants and their reaction to abiotic stresses. However, little is known...
Delivering gene therapy for mucopolysaccharide diseases
19/09/2022 - Mucopolysaccharide diseases are a group of paediatric inherited lysosomal storage diseases that are caused by enzyme deficiencies, leading to a build-up of glycosaminoglycans (GAGs) throughout the...
Riboswitch-mediated regulation of riboflavin biosynthesis genes in prokaryotes
19/09/2022 - Abstract Prokaryotic organisms frequently use riboswitches to quantify intracellular metabolite concentration via high-affinity metabolite receptors. Riboswitches possess a...
Bacterial biomarkers capable of identifying recurrence or metastasis carry disease severity information for lung cancer
19/09/2022 - BackgroundLocal recurrence and distant metastasis are the main causes of death in patients with lung cancer. Multiple studies have described the recurrence or metastasis of lung cancer at the...
Reports of acute adverse events in mRNA COVID-19 vaccine recipients after the first and second doses in Japan
19/09/2022 - Scientific Reports, Published online: 15 September 2022; doi:10.1038/s41598-022-19936-5Reports of acute adverse...
The Dysfunction of Carcinogenesis- and Apoptosis-Associated Genes that Develops in the Hypothalamus under Chronic Social Defeat Stress in Male Mice
19/09/2022 - Abstract Chronic social stress caused by daily agonistic interactions in male mice leads to a mixed anxiety/depression-like disorder that is accompanied by the development of...
A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes
19/09/2022 - Abstract The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds...
Expression patterns of the poplar NF-Y gene family in response to Alternaria alternata and hormone treatment and the role of PdbNF-YA11 in disease resistance
19/09/2022 - Plant nuclear factor-Y (NF-Y) transcription factors (TFs) are key regulators of growth and stress resistance. However, the role of NF-Y TFs in poplar in response to biotic stress is still unclear....
Utilization of Receptor-Binding Domain of SARS-CoV-2 Spike Protein Expressed in Escherichia coli for the Development of Neutralizing Antibody Assay
19/09/2022 - Abstract The ongoing COVID-19 pandemic has resulted from widespread infection by the SARS-CoV-2 virus. As new variants of concern continue to emerge, understanding the correlation...
Biosurfactants in the sustainable eradication of SARS COV-2 from the environmental surfaces
19/09/2022 - Abstract The COVID-19 outbreak has brought the world, at least, to one consensus that cleanliness is unavoidable under all circumstances. Hands are the main body part to...
3-Dimensional coculture of breast cancer cell lines with adipose tissue–Derived stem cells reveals the efficiency of oncolytic Newcastle disease virus infection via labeling technology
19/09/2022 - Oncolytic virotherapy is one of the emerging biological therapeutics that needs a more efficient in vitro tumor model to overcome the two-dimensional (2D) monolayer tumor cell culture model’s...
Exploring the potential of endophytes and their metabolites for bio-control activity
19/09/2022 - Abstract In the current scenario, extensive use of synthetic chemicals in agriculture is creating notable problems such as disease and pest resistance, residues, yield loss, and...