Biotecnología

Biotecnología

IMPRESCINDIBLE

Imágenes 3D in vivo del desarrollo de vasos intersegmentarios del zebrafish mediante un microscopio de iluminación de hoja de luz bidireccional

13/04/2021 - In-vivo 3D imaging of Zebrafish’s intersegmental vessel development by a bi-directional light-sheet illumination microscope

IMPRESCINDIBLE

Microambientes hematopoyéticos humanos

21/04/2021 - Utilizando información combinada, se realizó una cuantificación no asistida por computadora de nueve componentes de la médula ósea (adipocitos, megacariocitos, superficies óseas, cuatro tipos de vasos diferentes (arterias, capilares, sinusoides y senos colectores), otras "células madre hematopoyéticas y progenitores multipotentes" y otros "progenitores") dentro de los 30 ?m de "células madre hematopoyéticas y progenitores multipotentes", "progenitores" y "perfiles celulares aleatorios". Se mostró que el microambiente de las “células madre hematopoyéticas y progenitores multipotentes” está significativamente enriquecido en sinusoides y megacariocitos, mientras que el microambiente de los “progenitores” está significativamente enriquecido en capilares, otros “progenitores”, superficies óseas y arterias.

IMPRESCINDIBLE

Imágenes del cancer célula por célula

17/05/2021 - Imaging cancer cell by cell La experiencia en el tratamiento del cáncer colorrectal muestra que la inhibición de la vía de señalización de la proteína quinasa activada por mitógenos activada por oncogén (MAPK) suele ser más eficaz si también se inhibe la actividad del receptor del factor de crecimiento epidérmico, que actúa corriente arriba para activar la vía. Para ayudar a aclarar cómo podría funcionar dicho tratamiento combinado, Ponsioen et al. utilizaron imágenes unicelulares de la actividad de la quinasa regulada por señales extracelulares (ERK) de MAPK en organoides derivados de pacientes. La señalización inducida por oncogenes mostró que las oscilaciones en la actividad de ERK fueron amplificadas por la señalización del factor de crecimiento epidérmico. Los resultados ayudan a explicar cómo se han logrado mejores prácticas clínicas en el tratamiento del cáncer colorrectal.

IMPRESCINDIBLE

Impresión 3D in situ: oportunidades con tintas de seda

09/06/2021 - In Situ 3D Printing: Opportunities with Silk Inks In situ 3D printing is an emerging technique designed for patient-specific needs and performed directly in the patient’s tissues in the operating room. While this technology has progressed rapidly, several improvements are needed to push it forward for widespread utility, including ink formulations and optimization for in situ context. Silk fibroin inks emerge as a viable option due to the diverse range of formulations, aqueous processability, robust and tunable mechanical properties, and self-assembly via biophysical adsorption to avoid exogenous chemical or photochemical sensitizer additives, among other features. In this review, we focus on this new frontier of 3D in situ printing for tissue regeneration, where silk is proposed as candidate biomaterial ink due to the unique and useful properties of this protein polymer.

Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PRS17
09/06/2021 - ion>https://www.sciencedirect.com/science/article/pii/S0006291X21008858?dgcid=rss_sd_allhttps://www.sciencedirect.com/science/article/pii/S0006291X21008858Involvement of ferroptosis in human motor...
Courier service for phosphatidylinositol: PITPs deliver on demand
09/06/2021 - Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes including receptor-mediated...
Red-Light-Responsive Coordination Polymers Nanorods: New Strategy for Ultrasensitive Photothermal Detection of Targeted Cancer Cells
09/06/2021 - https://www.sciencedirect.com/science/article/pii/S0956566321004541?dgcid=rss_sd_allhttps://www.sciencedirect.com/science/article/pii/S0956566321004541Bipolar electrode ratiometric...
Unchecked nick ligation can promote localized genome re-replication
09/06/2021 - ription>https://www.sciencedirect.com/science/article/pii/S0960982221003821?dgcid=rss_sd_allhttps://www.sciencedirect.com/science/article/pii/S0960982221003821Dori DerdikmanPublication date: 7...
Current Knowledge on Beetroot Bioactive Compounds: Role of Nitrate and Betalains in Health and Disease
09/06/2021 - Dietary components, such as lactic acid bacteria (LAB), bovine colostrum, apple production by-products, and essential oils, can favorably alter the host immune system and gut microbiota, however,...
Comparative Genomics of Clostridium perfringens Reveals Patterns of Host-Associated Phylogenetic Clades and Virulence Factors
09/06/2021 - Clostridium perfringens is an opportunistic pathogenic bacterium that infects both animals and humans. Clostridium perfringens genomes encode a diverse array of toxins and virulence proteins,...
Impact of Alcohol Abuse on Susceptibility to Rare Neurodegenerative Diseases
09/06/2021 - Despite the prevalence and well-recognized adverse effects of prenatal alcohol exposure and alcohol use disorder in the causation of numerous diseases, their potential roles in the etiology of...
Occurrence of Endoparasites in Adult Swedish Dogs: A Coprological Investigation
09/06/2021 - The occurrence of endoparasites in Swedish adult dogs (n = 303) was investigated between January and October 2014. Included dogs had to be clinically healthy, older than 1 year and untreated with...
In-process monitoring of microscale grain protrusions by tracing impulse-discharge energy related to thermal transmission balance on diamond cutting interface
09/06/2021 - Stable ground surface depends on abrasive grain protrusions, but it has no way to monitor the wheel topographical state during grinding. Generally, the charge coupled device (CCD) monitoring is...
A grey whale makes an epic swim into the record books
09/06/2021 - Nature, Published online: 08 June 2021; doi:10.1038/d41586-021-01521-xScientists — be political in the good...
Integration of massive single-cell datasets
09/06/2021 - Nature Methods, Published online: 07 June 2021; doi:10.1038/s41592-021-01190-8The iNMF algorithm efficiently...
Pregnancy-induced effects on memory B-cell development in multiple sclerosis
09/06/2021 - Scientific Reports, Published online: 09 June 2021; doi:10.1038/s41598-021-91655-9Pregnancy-induced effects on...
Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer
09/06/2021 - Sequential treatment with endocrine or chemotherapy is generally used in the treatment of estrogen receptor (ER)-positive recurrent breast cancer. To date, few studies have investigated the effect of...