Biotecnología

Biotecnología

IMPRESCINDIBLE

Agricultura molecular: la curva de la consolidación

20/01/2020 - La agricultura molecular se puede definir como el uso de plantas para producir productos proteicos recombinantes. La tecnología tiene más de 30 años. La promesa inicial de la agricultura molecular se basó en tres ventajas percibidas: los bajos costos del cultivo de plantas, la inmensa escalabilidad de la producción agrícola y la seguridad inherente de las plantas como anfitriones para la producción de productos farmacéuticos. Hubo un grado moderado de éxito para las empresas que producen proteínas no farmacéuticas, pero en el sector farmacéutico la espectativa generada por la investigación inicial prometedora se encontró con la fría realidad del pragmatismo industrial. A principios de la década de 2000, los principales actores de la industria comenzaron a perder interés y la agricultura molecular farmacéutica cayó de un pico de expectativa a un punto de desilusión, tal como lo predijo el ciclo de exageración de Gartner. Muchos de los pioneros de la agricultura molecular han reenfocado sus actividades y han trabajado para abordar las limitaciones que obstaculizaron la primera generación de tecnologías. El campo ahora se ha consolidado en torno a un número menor de plataformas mejor caracterizadas y ha comenzado a desarrollar métodos estandarizados y mejores prácticas, reflejando la evolución de sectores industriales más maduros. Del mismo modo, la atención pasó de los estudios de prueba de principios al modelo tecnoeconómico realista para capturar mercados de nicho significativos, replicando el éxito del sector industrial de agricultura molecular. Estos desarrollos recientes significan que la agricultura molecular farmacéutica ahora está subiendo la cuesta de la consolidación y pronto surgirá como una tecnología madura.

Are women publishing less during the pandemic? Here’s what the data say
21/05/2020 - Nature, Published online: 20 May 2020; doi:10.1038/d41586-020-01443-0The latest science news, in brief.
Ling-gui-zhu-gan decoction alleviates hepatic steatosis through SOCS2 modification by N6-methyladenosine
21/05/2020 - https://www.sciencedirect.com/science/article/pii/S0753332220301669?dgcid=rss_sd_allhttps://www.sciencedirect.com/science/article/pii/S0753332220301669The IL-33/ST2 pathway suppresses murine colon...
Experimental study on the characteristics of the explosive boiling induced by the pressure relief at the top of vertical vessels
21/05/2020 - In this study, the explosive boiling process of a superheated liquid induced by the pressure relief at the top of a vertical vessel was experimentally investigated. The response of the pressure at...
Indigenous Bacteria Have High Potential for Promoting Salix integra Thunb. Remediation of Lead-Contaminated Soil by Adjusting Soil Properties
21/05/2020 - Salix integra Thunb., a fast-growing woody plant species, has been used for phytoremediation in recent years. However, little knowledge is available regarding indigenous soil microbial communities...
Analytical performance of thrombospondin-1 and cathepsin D immunoassays part of a novel CE-IVD marked test as an aid in the diagnosis of prostate cancer
21/05/2020 - The Prostate Specific Antigen (PSA) test suffers from low specificity for the diagnosis of Prostate Cancer (PCa). We originally discovered two cancer-related proteins thrombospondin-1 (THBS1) and...
Canine hip dysplasia screening: Comparison of early evaluation to final grading in 231 dogs with Fédération Cynologique Internationale A and B
21/05/2020 - Objectives This study aimed to verify if a significant difference exists between parameters in the early evaluation of normal and near-normal hip joints, to evaluate the influence of age and breed...
Live-cell protein engineering with an ultra-short split intein [Chemistry]
21/05/2020 - Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated host response to an infection. Here we report that the circulating levels of growth and differentiation factor-15...
Optimization of Method for Human Sex Determination Using Peptidome Analysis of Teeth Enamel from Teeth of Different Biological Generation, Archeological Age, and Degrees of Taphonomic Preservation
21/05/2020 - Abstract Determination of biological sex to human remains is a fundamental requirement in anthropological, archeological, and forensic anthropological studies. Sex...
Terminal Deoxynucleotidyl Transferase induced activators to unlock the trans-cleavage of CRISPR/Cpf 1 (TdT-IU- CRISPR/Cpf 1): An ultra-sensitive biosensor for Dam MTase activity detection
21/05/2020 - https://www.sciencedirect.com/science/article/pii/S0956566320302669?dgcid=rss_sd_allhttps://www.sciencedirect.com/science/article/pii/S0956566320302669Nano-enabled sensing approaches for pathogenic...
Correction to: Identification of passion fruit ( Passiflora edulis ) chromosomes using BAC-FISH
21/05/2020 - The article “Identification of passion fruit (Passiflora edulis) chromosomes using BAC-FISH,” written by Mariela A. Sader, Yhanndra Dias, Zirlane P. da Costa, Carla Munhoz, Helen Penha,...
How to build complexity
21/05/2020 - ription>https://www.sciencedirect.com/science/article/pii/S096098222030628X?dgcid=rss_sd_allhttps://www.sciencedirect.com/science/article/pii/S096098222030628XThe long dark teatime of the...
Fungistatic and Fungicidal Capacity of a Biosurfactant Extract Obtained from Corn Steep Water
21/05/2020 - Chia seeds and chia flour could be used as ingredients to enrich foods owing to their high amount of nutrients. The goal of this investigation was to provide further information about how replacing...
Precision Antifungal Treatment Significantly Extends Voice Prosthesis Lifespan in Patients Following Total Laryngectomy
21/05/2020 - Indwelling silicone valves called voice prostheses (VPs) are the gold standard for speech rehabilitation in patients with laryngeal cancer following total laryngectomy. Reported VP lifespans...
miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples
21/05/2020 - Lung cancer is still one of the leading cause of death worldwide. The clinical variability of lung cancer is high and drives treatment decision. In this context, correct discrimination of...
WHO: Strengthen Nurse Workforce
21/05/2020 - An urgent global effort is needed to bolster the nurse workforce, according to a report from the World Health Organization (WHO), the International Council of Nurses, and Nursing Now, an...
Infectious Disease Outbreaks, Pandemics, and Hollywood—Hope and Fear Across a Century of Cinema
21/05/2020 - This Arts and Medicine feature tallies the appearance of infectious disease outbreaks in cinema since 1914, and identifies common themes, such as stigmatization and physician heroism, that...
Optimizing the Trade-off Between Learning and Doing in the COVID-19 Pandemic
21/05/2020 - This Viewpoint discusses the tensions between evaluating treatments (learning) and just treating patients (doing) during the coronavirus disease 2019 (COVID-19) pandemic, and proposes actions the...
Mapping livestock movements in Sahelian Africa
21/05/2020 - Scientific Reports, Published online: 20 May 2020; doi:10.1038/s41598-020-65132-8Mapping livestock movements in...