Biotecnología
Biotecnología
Resurrection of 2?-5?-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication
01/12/2023 -
The prenylated form of the human 2?-5?-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),...
Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study
01/12/2023 -
Background Vaccines have reduced severe disease and death from Coronavirus Disease 2019 (COVID-19). However, with evidence of waning efficacy coupled with continued evolution of the virus, health...
Safety, immunogenicity and efficacy of an mRNA-based COVID-19 vaccine, GLB-COV2-043, in preclinical animal models
01/12/2023 -
Scientific Reports, Published online: 01 December 2023; doi:10.1038/s41598-023-46233-6Safety, immunogenicity...
Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)
01/12/2023 -
Proceedings of the National Academy of Sciences, Volume 120, Issue 49, December 2023.
Vaccination, immunity, and the changing impact of COVID-19 on infant health
01/12/2023 -
Proceedings of the National Academy of Sciences, Volume 120, Issue 49, December 2023.
The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress
01/12/2023 -
Proceedings of the National Academy of Sciences, Volume 120, Issue 49, December 2023.
Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro, and safety for application to COVID-19 patients in a pilot clinical study
01/12/2023 -
Coronaviruses are the causative agents of several recent outbreaks, including the COVID-19 pandemic. One therapeutic approach is blocking viral binding to the host receptor. As binding largely...
The impact of COVID-19 pandemic on pet behavior and human-animal interaction: a longitudinal survey-based study in the United States
01/12/2023 -
IntroductionAlthough multiple studies have explored behavioral changes in pets during the strict lockdown of the COVID-19 pandemic between May and July 2020, this longitudinal study uniquely...
Homogeneous liquid–liquid microextraction coupled with HPLC/DAD for determination of nirmatrelvir and ritonavir as COVID-19 combination therapy in human plasma
28/11/2023 -
The study reports the development of a high-performance liquid chromatography/diode array detection method to measure the levels of nirmatrelvir and ritonavir in human plasma. These two antiviral...
Synthesis, characterization, DNA binding interactions, DFT calculations, and Covid-19 molecular docking of novel bioactive copper(I) complexes developed via unexpected reduction of azo-hydrazo ligands
22/11/2023 -
In this work, we focused on the 3rd goal of the sustainable development plan: achieving good health and supporting well-being. Two redox-active hydrazo ligands namely,...
National Danish surveillance of invasive clinical Haemophilus influenzae isolates and their resistance profile
22/11/2023 -
IntroductionThis study aimed to investigate the epidemiology, serotype distribution, phenotypical antibiogram, and molecular resistance gene characteristics of invasive Haemophilus influenzae...
An open-source, automated, and cost-effective platform for COVID-19 diagnosis and rapid portable genomic surveillance using nanopore sequencing
22/11/2023 -
https://www.nature.com/articles/s41598-023-47190-w
Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study
21/11/2023 -
Scientific Reports, Published online: 19 November 2023; doi:10.1038/s41598-023-47539-1Dysregulations in...
Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1
21/11/2023 -
https://www.nature.com/articles/s41598-023-47511-z
Psoriasis comorbidity management in the COVID era: a pressing challenge
15/11/2023 -
The global COVID-19 pandemic has presented a significant, ongoing challenge since its emergence in late 2019. Today, the Omicron strain, which is less lethal but more contagious than the original...
Minding the “T”s beyond the “B”s: Shaping vaccines for future pandemics
09/11/2023 -
The COVID-19 pandemic has accelerated the development of vaccines for viral infections. However, a failure to integrate T cell immunity as a determinant of vaccine efficacy could curtail advancement...
Diclofenac, ibuprofen, and paracetamol biodegradation: overconsumed non-steroidal anti-inflammatories drugs at COVID-19 pandemic
30/10/2023 -
The consumption of non-steroidal anti-inflammatory drugs (NSAIDs) have increased significantly in the last years (2020–2022), especially for patients in COVID-19 treatment. NSAIDs such as...
Effects of wearing masks during COVID-19 pandemic on the composition and diversity of skin bacteria and fungi in medical workers
27/10/2023 -
BackgroundAlthough studies have shown that wearing masks can affect the skin microbiome, more detailed and comprehensive research on wearing masks needs to be further explored.ObjectiveThis...
Author Correction: Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes
27/10/2023 -
Scientific Reports, Published online: 26 October 2023; doi:10.1038/s41598-023-45343-5Author Correction:...
Serum interleukin-6, procalcitonin, and C-reactive protein at hospital admission can identify patients at low risk for severe COVID-19 progression
23/10/2023 -
BackgroundCOVID-19 can show a variable course, from asymptomatic infections to acute respiratory failure and death. For efficient allocation of resources, patients should be stratified according...
