Biotecnología
Biotecnología
Evaluation of SgK269 expression in colon cancer patients and the effects of hAMSCs secretome on tumor invasion through SgK269/c-Src/p-P130Cas/p-Paxillin/p-ERK1/2 signaling pathway in HT-29 colon cancer cells
27/09/2023 -
Abstract Colon cancer is the fifth leading cause of cancer-related deaths worldwide. Stem cells have unique characteristics and are considered as a novel therapeutic platform...
HPLC/UV approach method for the first simultaneous estimation of molnupiravir and ertapenem as a binary mixture in human plasma and dosage form as a regimen for COVID-19 treatments
27/09/2023 -
COVID-19 is a serious virus that can have a lot of effects, one of which is a secondary bacterial infection that can be more life-threatening and even lethal than the initial viral infection. Hence a...
State-of-the-Art Approaches to Heterologous Expression of Bispecific Antibodies Targeting Solid Tumors
27/09/2023 -
Abstract Bispecific antibodies (bsAbs) are some of the most promising biotherapeutics due to the versatility provided by their structure and functional features. bsAbs...
An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004–2020)
27/09/2023 -
ObjectivesTo describe and analyse erythromycin resistance trends in blood isolates of Staphylococcus aureus (EARS-Net Spain, 2004–2020) and the association of these trends with the consumption...
Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes
27/09/2023 -
Nature Biotechnology, Published online: 25 September 2023; doi:10.1038/s41587-023-01931-4Lineage tracing using...
Synergistic biocontrol of Bacillus subtilis and Pseudomonas fluorescens against early blight disease in tomato
27/09/2023 -
Abstract Early blight of tomato caused by Alternaria solani results in significant crop losses. In this study, Bacillus subtilis J3 and Pseudomonas fluorescens J8 were...
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
27/09/2023 -
The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with...
Upregulation of YciM Expression Reduces Endotoxin Contamination of Recombinant Proteins Produced in Escherichia coli Cells
27/09/2023 -
Abstract Recombinant proteins produced in Escherichia coli are often contaminated with endotoxins, which can be a serious problem for their further application. One of the...
Comparative assessment of Alzheimer’s disease-related biomarkers in plasma and neuron-derived extracellular vesicles: a nested case-control study
27/09/2023 -
Introduction: Alzheimer’s disease (AD) is currently defined according to biomarkers reflecting the core underlying neuropathological processes: A? deposition, Tau, and neurodegeneration (ATN)....
Garnet microstructures suggest ultra-fast decompression of ultrahigh-pressure rocks
27/09/2023 -
Nature Communications, Published online: 27 September 2023; doi:10.1038/s41467-023-41699-4Viruses are...
Biochar amendment reassembles microbial community in a long-term phosphorus fertilization paddy soil
27/09/2023 -
Abstract This study investigates the effect of biochar amendment on microbial community structure and soil nutrient status in paddy soil that has been fertilized for an...
Role of Legionella pneumophila outer membrane vesicles in host-pathogen interaction
27/09/2023 -
Legionella pneumophila is an opportunistic intracellular pathogen that inhabits artificial water systems and can be transmitted to human hosts by contaminated aerosols. Upon inhalation, it...
Analysis of Some Biochemical Properties of Recombinant Siberian Roe Deer (Capreolus pygargus) Chymosin Obtained in the Mammalian Cell Culture (CHO-K1)
27/09/2023 -
Abstract Structure of the chymosin gene of Siberian roe deer (Capreolus pygargus) was established for the first time and its exon/intron organization was determined. Coding...
Elevated expression of glycolytic genes as a prominent feature of early-onset preeclampsia: insights from integrative transcriptomic analysis
27/09/2023 -
Introduction: Preeclampsia (PE), a notable pregnancy-related disorder, leads to 40,000+ maternal deaths yearly. Recent research shows PE divides into early-onset (EOPE) and late-onset (LOPE)...
Large numbers of patients are needed to obtain additional approvals for new cancer drugs: A retrospective cohort study
27/09/2023 -
Scientific Reports, Published online: 26 September 2023; doi:10.1038/s41598-023-42213-yLarge numbers of...
Regulation of nutrient utilization in filamentous fungi
27/09/2023 -
Abstract Organisms must accurately sense and respond to nutrients to survive. In filamentous fungi, accurate nutrient sensing is important in the establishment of fungal...
Non-Immunoglobulin Synthetic Binding Proteins for Oncology
27/09/2023 -
Abstract Extensive application of technologies like phage display in screening peptide and protein combinatorial libraries has not only facilitated creation of new recombinant...
Early supplementation with zinc proteinate does not change rectal microbiota but increases growth performance by improving antioxidant capacity and plasma zinc concentration in preweaned dairy calves
27/09/2023 -
The present study evaluated the effects of early supplementation with zinc proteinate (ZnP) or zinc oxide (ZnO) for 2?weeks on the growth performance, redox status, plasma trace element...
Fabrication and evaluation of vitamin doped Zno/AgNPs nanocomposite based wheat gluten films: a promising findings for burn wound treatment
27/09/2023 -
https://www.nature.com/articles/s41598-023-43413-2
Novel B-Cell Epitopes of Non-Neutralizing Antibodies in the Receptor-Binding Domain of the SARS-CoV-2 S-Protein with Different Effects on the Severity of COVID-19
27/09/2023 -
Abstract Antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein (RBD S-protein) contribute significantly to the humoral immune response during...
