Biotecnología
Biotecnología
Extraction of the outer membrane protein pertactin from Bordetella pertussis with urea for the production of acellular pertussis vaccine
23/07/2024 -
Abstract Pertactin (PRN), a non-fimbrial outer membrane protein of Bordetella pertussis, is the limiting component of the acellular pertussis vaccine because of its low...
Enhanced production of lactic acid from pretreated rice straw using co-cultivation of Bacillus licheniformis and Bacillus sonorenesis
10/07/2024 -
Abstract Lactic acid (LA) production from sugar mixture derived from lignocellulosic rice straw employing co- culture system of thermotolerant and inhibitor tolerant Bacillus...
Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity
19/01/2024 -
Abstract During in vitro culture, human pluripotent stem cells (hPSCs) often acquire survival advantages characterized by decreased susceptibility to mitochondrial cell death,...
Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-?B signaling in colorectal cancer
19/01/2024 -
Abstract Colorectal cancer (CRC) is characterized by a complex tumor inflammatory microenvironment, while angiogenesis and immunosuppression frequently occur concomitantly....
G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer
19/01/2024 -
Abstract P38? (MAPK12) is predominantly expressed in triple negative breast cancer cells (TNBC) and induces stem cell (CSC) expansion resulting in decreased survival of the...
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids
19/01/2024 -
Abstract N-methyl-d-aspartate receptors (NMDARs) play a critical role in normal brain function, and variants in genes encoding NMDAR subunits have been described in individuals...
Increasing HbA1c is associated with reduced CD8+ T cell functionality in response to influenza virus in a TCR-dependent manner in individuals with diabetes mellitus
19/01/2024 -
Abstract Diabetes mellitus is on the rise globally and is a known susceptibility factor for severe influenza virus infections. However, the mechanisms by which diabetes...
Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance
19/01/2024 -
Abstract Background Dysbiosis of gut microbiota is frequent in liver cirrhosis (LC) patients, and splenectomy (SP) has been reported...
Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice
19/01/2024 -
Abstract The mechanism underlying the transition from the pre-symptomatic to the symptomatic state is a crucial aspect of epileptogenesis. SYN2 is a member of a multigene family...
Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer
19/01/2024 -
Abstract Although amplifications and mutations in receptor tyrosine kinases (RTKs) act as bona fide oncogenes, in most cancers, RTKs maintain moderate expression and remain...
Knockdown of NEAT1 prevents post-stroke lipid droplet agglomeration in microglia by regulating autophagy
19/01/2024 -
Abstract Background Lipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are...
Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota
19/01/2024 -
Weaning is undoubtedly one of the most crucial stages in the growth and development of all mammalian animals, including donkey foals. Weaning is a dynamic and coordinated process of the body,...
Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction
19/01/2024 -
Abstract This review provides an update on recent findings from basic, translational, and clinical studies on the molecular mechanisms of mitochondrial dysfunction and apoptosis...
Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases
19/01/2024 -
Abstract The intricate relationship between the central nervous system (CNS) and the immune system plays a crucial role in the pathogenesis of various neurological diseases....
Mechano-regulation by clathrin pit-formation and passive cholesterol-dependent tubules during de-adhesion
19/01/2024 -
Abstract Adherent cells ensure membrane homeostasis during de-adhesion by various mechanisms, including endocytosis. Although mechano-chemical feedbacks involved in this process...
Lactic acid promotes nucleus pulposus cell senescence and corresponding intervertebral disc degeneration via interacting with Akt
19/01/2024 -
Abstract The accumulation of metabolites in the intervertebral disc is considered an important cause of intervertebral disc degeneration (IVDD). Lactic acid, which is a...
Multiple circulating forms of neprilysin detected with novel epitope-directed monoclonal antibodies
19/01/2024 -
Abstract Neprilysin (NEP) is an emerging biomarker for various diseases including heart failure (HF). However, major inter-assay inconsistency in the reported concentrations of...
Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
19/01/2024 -
Abstract Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are two of the nine...
Secrets and lies of host–microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases
19/01/2024 -
Abstract Here we critically discuss data supporting the view that microbial agents (pathogens, pathobionts or commensals alike) play a relevant role in the pathogenesis of...
Tryptophanylation of insulin receptor by WARS attenuates insulin signaling
19/01/2024 -
Abstract Increased circulating amino acid levels have been linked to insulin resistance and development of type 2 diabetes (T2D), but the underlying mechanism remains largely...
