Biotecnología
Biotecnología
Stable two- and three-dimensional cholangiocyte culture systems from extrahepatic bile ducts of biliary atresia patients: use of structural and functional bile duct epithelium models for in vitro analyses
16/04/2024 -
Abstract We herein report two- (2D) and three-dimensional (3D) culture methods of cholangiocytes originating from extrahepatic bile ducts of biliary atresia (BA) patients. Cells...
The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro
16/04/2024 -
Abstract Potential role and associated mechanisms of Annexin A8 (ANXA8), a member of the Annexins family, in cervical squamous cell carcinoma (CESC) are still unclear, despite...
Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation
16/04/2024 -
Abstract Ferroptosis is a unique form of cell death reliant on iron and lipid peroxidation. It disrupts redox balance, causing cell death by damaging the plasma membrane, with...
Recombinant Amidases: Recent Insights and its Applications in the Production of Industrially Important Fine Chemicals
16/04/2024 -
Abstract The current research for the synthesis of industrially important fine chemicals is more inclined towards developing enzyme-based processes. The biotransformation...
Comprehensive assessment of goat adipose tissue-derived mesenchymal stem cells cultured in different media
16/04/2024 -
https://www.nature.com/articles/s41598-024-58465-1
Degranulation of RBL-2H3 rat basophilic leukemia cells is synergistically inhibited by combined treatment with nobiletin and lactoferrin
08/04/2024 -
Abstract The aim of this study was to elucidate the anti-allergic effects of polymethoxyflavonoids in combination with milk proteins and the mechanism of inhibition. Three...
The Predictive Value of Neutrophil Extracellular Trap-Related Risk Score in Prognosis and Immune Microenvironment of Colorectal Cancer Patients
08/04/2024 -
Abstract Colorectal cancer (CRC) has brought great healthy burden for patients. Neutrophil extracellular traps (NETs) have been explored in several tumors, while it remains...
The Evolving Landscape of Cervical Cancer: Breakthroughs in Screening and Therapy Through Integrating Biotechnology and Artificial Intelligence
08/04/2024 -
Abstract Cervical cancer (CC) continues to be a major worldwide health concern, profoundly impacting the lives of countless females worldwide. In low- and middle-income countries...
Prognostic Model Construction of Disulfidptosis-Related Genes and Targeted Anticancer Drug Research in Pancreatic Cancer
08/04/2024 -
Abstract Pancreatic cancer stands as one of the most lethal malignancies, characterized by delayed diagnosis, high mortality rates, limited treatment efficacy, and poor prognosis....
EHMT2 Suppresses ARRB1 Transcription and Activates the Hedgehog Signaling to Promote Malignant Phenotype and Stem Cell Property in Oral Squamous Cell Carcinoma
08/04/2024 -
Abstract Oral squamous cell carcinoma (OSCC) represents the primary subtype of head and neck squamous cell carcinoma (HNSCC), characterized by a high morbidity and mortality rate....
Suppression of JAK2/STAT3 Pathway by Notoginsenoside R1 Reduces Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer
08/04/2024 -
Abstract It has bene reported that a novel saponin-notoginsenoside R1 (NGR1) possesses strong anti-tumor activities. This study aimed to investigate the role and mechanism of NGR1...
From Data to Cure: A Comprehensive Exploration of Multi-omics Data Analysis for Targeted Therapies
08/04/2024 -
Abstract In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards understanding underlying disease mechanisms, placing a strong emphasis on molecular...
Biodegradable suture development-based albumin composites for tissue engineering applications
08/04/2024 -
https://www.nature.com/articles/s41598-024-58194-5
Intimate contact between red blood cells and vessel walls is sufficient to stabilize capillary networks during development
08/04/2024 -
Proceedings of the National Academy of Sciences, Volume 121, Issue 14, April 2024.
Utah flouts FDA with law greenlighting placental stem cell therapies
08/04/2024 -
Measure declares that regulatory agency can be ignored and patients given unapproved treatments
Comment on 'Making the biochemical conversion of lignocellulose more robust'
08/04/2024 -
In the opinion paper by Zhao et al. ‘Making the biochemical conversion of lignocellulose more robust’, the authors claim that ‘…lignocellulose biorefinery is conceptually wrong’. In...
Droplet-based cell-laden microgels for high-throughput analysis
08/04/2024 -
The surge in ‘Big data’ has significantly influenced biomaterials research and development, with vast data volumes emerging from clinical trials, scientific literature, electronic health records,...
Making the biochemical conversion of lignocellulose more robust
08/04/2024 -
Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore...
Synthetic transcription factor engineering for cell and gene therapy
08/04/2024 -
Since the first administration of insulin to a person with diabetes in 1922, scientific contributions from academia and industry have improved insulin therapy and access. The pharmaceutical need for...
Targeting biofilm infections in humans using small scale robotics
08/04/2024 -
Nature often uses dynamically assembling multienzymatic complexes called metabolons to achieve spatiotemporal control of complex metabolic reactions. Researchers are aiming to mimic this strategy of...
Make better, data-backed decisions to hit biotech milestones faster
08/04/2024 -
10.1016/j.tibtech.2023.11.011 Trends in Biotechnology 42, 4 (2024) 2024-01-03 Trends in Biotechnology 2024-01-03 42 4 S0167-7799(23)X0005-5 Industry Highlight ...
