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Location and Orientation of the Genetic Toxin–Antitoxin Element hok/sok in the Plasmid Affect Expression of Pharmaceutically Significant Proteins in Bacterial Cells
Abstract Genetic toxin–antitoxin element hok/sok from the natural Escherichia coli R1 plasmid ensures segregational stability of plasmids. Bacterial cells that have lost...
Development of Heterologous Expression System and Optimization of the Method of Cholera Toxin ?-Subunit Production in E. coli
Abstract Cholera is a deadly infection disease, which is usually associated with low hygiene levels and limited access to high-quality drinking water. An effective way to...
Early supplementation with zinc proteinate does not change rectal microbiota but increases growth performance by improving antioxidant capacity and plasma zinc concentration in preweaned dairy calves
The present study evaluated the effects of early supplementation with zinc proteinate (ZnP) or zinc oxide (ZnO) for 2?weeks on the growth performance, redox status, plasma trace element...
Reconstitution of Calcium Channel Protein Orai3 into Liposomes for Functional Studies
Abstract Store-operated calcium entry (SOCE) is the main mechanism for the Ca2+ influx in non-excitable cells. The two major components of SOCE are stromal interaction...
Effect of Biotin Starvation on Gene Expression in Komagataella phaffii Cells
Abstract Methylotrophic yeast Komagataella phaffii is widely used in biotechnology for recombinant protein production. Due to the practical significance of these yeasts, it is...
Influence on Accumulation Levels and Subcellular Localization of Prolamins by Fusion with the Functional Peptide in Transgenic Rice Seeds
Abstract To exploit the rice seed-based oral vaccine against Sjögren’s syndrome, altered peptide ligand of N-terminal 1 (N1-APL7) from its M3 muscarinic acetylcholine...
Heterologous Expression of Recombinant Proteins and Their Derivatives Used as Carriers for Conjugate Vaccines
Abstract Carrier proteins that provide an effective and long-term immune response to weak antigens has become a real breakthrough in the disease prevention, making it...
Dimeric ACE2-FC Is Equivalent to Monomeric ACE2 in the Surrogate Virus Neutralization Test
Abstract Angiotensin-converting enzyme 2 (ACE2) is the main cellular receptor for the dangerous sarbecoviruses SARS-CoV and SARS-CoV-2. Its recombinant extracellular domain is...
Daily briefing: Critics call consciousness theory ‘pseudoscience’
Nature, Published online: 20 September 2023; doi:10.1038/s41586-023-06493-8Global effects of marine protected...
Recent Developments in Bioprocessing of Recombinant Antibody Fragments
Abstract Biotechnological and biomedical applications of antibodies have been on a steady rise since the 1980s. As unique and highly specific bioreagents, monoclonal...
Impaired Enzymatic Antioxidant Defense in Erythrocytes of Rats with Ammonia-Induced Encephalopathy: Role of NMDA Receptors
Abstract Hepatic encephalopathy (HE), a neuropsychiatric disorder developing in patients with severe hepatic dysfunction, has been known for more than a century. However,...
From air to your plate: tech startups making food from atmospheric CO2
Nature Biotechnology, Published online: 26 September 2023; doi:10.1038/s41587-023-01992-5Food tech companies...
NAD+-Dependent Formate Dehydrogenase from Themotolerant Yeast Ogataea parapolymorpha: Properties and Protein Engineering of the N-Terminal Sequence
Abstract Previously, the gene of formate dehydrogenase (FDH, EC 126.96.36.199) from the thermotolerant methylotrophic yeast Ogataea parapolymorpha DL 1 (OpaFDH) was cloned in our...
Production and Characterization of Photorin, a Novel Proteinaceous Protease Inhibitor from the Entomopathogenic Bacteria Photorhabdus laumondii
Abstract Entomopathogenic bacteria of the genus Photorhabdus secrete protease S (PrtS), which is considered a virulence factor. We found that in the Photorhabdus genomes,...
Vector BioPharma: resurrecting adenoviral gene delivery
Nature Biotechnology, Published online: 26 September 2023; doi:10.1038/d41587-023-00012-wTwo veteran protein...
CRISPR/Cas9-Mediated Genome Editing of the Komagataella phaffii to Obtain a Phytase-Producer Markerless Strain
Abstract Using CRISPR/Cas9 system, the recipient strains K. phaffii VKPM Y-5013 (His– phenotype) and K. phaffii VKPM Y-5014 (Leu– phenotype) were derived from the...
State-of-the-Art Approaches to Heterologous Expression of Bispecific Antibodies Targeting Solid Tumors
Abstract Bispecific antibodies (bsAbs) are some of the most promising biotherapeutics due to the versatility provided by their structure and functional features. bsAbs...
Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes
Nature Biotechnology, Published online: 25 September 2023; doi:10.1038/s41587-023-01931-4Lineage tracing using...
Generation of a Cell Line Selectively Producing Functionally Active OATP1B1 Transporter
Abstract The solute carrier organic anion transporter family member, OATP1B1, is one of the most important transporter proteins, which mediate penetration of many endogenous...
Upregulation of YciM Expression Reduces Endotoxin Contamination of Recombinant Proteins Produced in Escherichia coli Cells
Abstract Recombinant proteins produced in Escherichia coli are often contaminated with endotoxins, which can be a serious problem for their further application. One of the...
Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens
Nature Biotechnology, Published online: 25 September 2023; doi:10.1038/s41587-023-01948-9mRNA kinetics are...
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