Biotecnología

Biotecnología

Characterization and spoilage potential of Bacillus cereus isolated from farm environment and raw milk
19/09/2022 - Bacillus cereus sensu lato (B. cereus sl) is important spoilage bacteria causing milk structure and flavor changes and is ubiquitous in the environment. This study addresses the biodiversity,...
Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome
19/09/2022 - Abstract Design and synthesis of conjugates consisting of the macrolide antibiotic desmycosin and fragments of the antibacterial peptide oncocin were performed in attempt to...
Millions are mourning the Queen — what’s the science behind public grief?
19/09/2022 - Nature, Published online: 14 September 2022; doi:10.1038/d41586-022-02860-zDrugs that direct the body’s...
Aggregation behavior of nanoparticles: Revisiting the phase diagram of colloids
19/09/2022 - Surface functionalization of metal nanoparticles (NPs), e.g., using peptides and proteins, has recently attracted a considerable attention in the field of design of therapeutics and diagnostics....
Glutamate as a non-conventional substrate for high production of the recombinant protein in Escherichia coli
19/09/2022 - The economic viability of the biomass-based biorefinery is readily acknowledged by implementation of a cascade process that produces value-added products such as enzymes prior to biofuels....
Mass Spectrometry-Based Chemical Proteomics for Drug Target Discoveries
19/09/2022 - Abstract —Chemical proteomics, emerging rapidly in recent years, has become a main approach to identifying interactions between the small molecules and proteins in the cells...
Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
19/09/2022 - Nature Biotechnology, Published online: 15 September 2022; doi:10.1038/s41587-022-01452-6A mostly natural...
Non-lysine ubiquitylation: Doing things differently
19/09/2022 - The post-translational modification of proteins with ubiquitin plays a central role in nearly all aspects of eukaryotic biology. Historically, studies have focused on the conjugation of ubiquitin...
Isobaric tags for relative and absolute quantification-based proteomic analysis of host-pathogen protein interactions in the midgut of Aedes albopictus during dengue virus infection
19/09/2022 - Aedes albopictus (Ae. albopictus), an important vector of dengue virus (DENV), is distributed worldwide. Identifying host proteins involved in flavivirus replication in Ae. albopictus and...
Plant Polysaccharide Array for Studying Carbohydrate-Binding Proteins
19/09/2022 - Abstract The specificity of the most plant carbohydrate-binding proteins (CBP), many of which are known only through bioinformatic analysis of the genome, has either not been...
Alchemab Therapeutics— Cracking the secrets of protective auto-immunity
19/09/2022 - Nature Biotechnology, Published online: 12 September 2022; doi:10.1038/d41587-022-00010-4Searching for...
CAT-CPI: Combining CNN and transformer to learn compound image features for predicting compound-protein interactions
19/09/2022 - Compound-protein interaction (CPI) prediction is a foundational task for drug discovery, which process is time-consuming and costly. The effectiveness of CPI prediction can be greatly improved...
Systemic tryptophan homeostasis
19/09/2022 - Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H),...
Spata2L Suppresses TLR4 Signaling by Promoting CYLD-Mediated Deubiquitination of TRAF6 and TAK1
19/09/2022 - Abstract Toll-like receptor 4 (TLR4) is a key pattern recognition receptor that can be activated by bacterial lipopolysaccharide to elicit inflammatory response. Proper...
Astrocyte Activation Markers
19/09/2022 - Abstract Astrocytes are the most common type of glial cells that provide homeostasis and protection of the central nervous system. Important specific characteristic of...
Exploring the RNase A scaffold to combine catalytic and antimicrobial activities. Structural characterization of RNase 3/1 chimeras
19/09/2022 - Design of novel antibiotics to fight antimicrobial resistance is one of the first global health priorities. Novel protein-based strategies come out as alternative therapies. Based on the...
Dynamic Modelling of DNA Repair Pathway at the Molecular Level: A New Perspective
19/09/2022 - DNA is the genetic repository for all living organisms, and it is subject to constant changes caused by chemical and physical factors. Any change, if not repaired, erodes the genetic information...
Neisseria gonorrhoeae: DNA Repair Systems and Their Role in Pathogenesis
19/09/2022 - Abstract Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative agent of gonorrhea, a sexually transmitted infection. The bacterium uses various...
Deletion Variants of Autotransporter from Psychrobacter cryohalolentis Increase Efficiency of 10FN3 Exposure on the Surface of Escherichia coli Cells
19/09/2022 - Abstract The autotransporter AT877 from Psychrobacter cryohalolentis belongs to the family of outer membrane proteins containing N-terminal passenger and C-terminal...
Unraveling key interactions and the mechanism of demethylation during hAGT-mediated DNA repair via simulations
19/09/2022 - Alkylating agents pose the biggest threat to the genomic integrity of cells by damaging DNA bases through regular alkylation. Such damages are repaired by several automated types of machinery...
Implication of non-coding RNA-mediated ROCK1 regulation in various diseases
19/09/2022 - Rho Associated Coiled-Coil Containing Protein Kinase 1 (ROCK1) is a protein serine/threonine kinase which is activated upon binding with the GTP-bound form of Rho. This protein can modulate...