Biotecnología

Biotecnología

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide
06/02/2023 - Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing...
Application of transposon insertion site sequencing method in the exploration of gene function in microalgae
06/02/2023 - Microalgae are a large group of organisms that can produce various useful substances through photosynthesis. Microalgae need to be genetically modified at the molecular level to become “Chassis...
Cell-free Biosynthesis of Peptidomimetics
06/02/2023 - Abstract A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein...
Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein
06/02/2023 - Nature Communications, Published online: 04 February 2023; doi:10.1038/s41467-023-35847-zIn this work, the...
Daily briefing: The surprising chemicals used to embalm Egyptian mummies
06/02/2023 - Nature, Published online: 02 February 2023; doi:10.1038/d41586-023-00124-yVaccination, infection with...
C. David Allis (1951–2023)
06/02/2023 - Nature, Published online: 03 February 2023; doi:10.1038/d41586-023-00334-4Some bacteria appear to encase their...
Docking and Molecular Dynamics Simulation Revealed the Potential Inhibitory Activity of Amygdalin in Triple-Negative Breast Cancer Therapeutics Targeting the BRCT Domain of BARD1 Receptor
06/02/2023 - Abstract Triple-negative breast cancer (TNBC), is diagnosed as the most lethal molecular subtype of breast cancer (BC) preceded by an extremely poor prognosis. For enabling...
Improving Catalytic Activity, Acid-Tolerance, and Thermal Stability of Glutathione Peroxidase by Systematic Site-Directed Selenocysteine Incorporation
06/02/2023 - Abstract Glutathione peroxidase (GPx) is an important antioxidant enzyme. Selenocysteine (Sec)-containing GPxs (Sec-GPxs) are usually superior to their conventional...
Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing
06/02/2023 - Abstract Osteoblast regeneration, characterized by osteoblast differentiation, is the basis of fracture healing and accelerates fracture repair. It has been reported that...
Quantitative comparison of protein-protein interaction interface using physicochemical feature-based descriptors of surface patches
06/02/2023 - Driving mechanisms of many biological functions in a cell include physical interactions of proteins. As protein-protein interactions (PPIs) are also important in disease development,...
Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies
03/02/2023 - Introduction: Extracellular vesicles (EVs) have emerged as a very attractive source of cancer- derived RNA biomarkers for the early detection, prognosis and monitoring of various cancers,...
Boletaceae in China: Taxonomy and phylogeny reveal a new genus, two new species, and a new record
03/02/2023 - Boletaceae, the largest family in Boletales, has been attracted by mycologists in the world due to its diverse morphology and complex history of evolution. Although considerable work has been done...
Identification of p72 epitopes of African swine fever virus and preliminary application
03/02/2023 - African swine fever virus (ASFV) causes a highly lethal hemorrhagic viral disease (ASF) of pigs that results in serious losses in China and elsewhere. The development of a vaccine and diagnosis...
Distributed compact plasma reactor decontamination for planetary protection in space missions
03/02/2023 - https://www.nature.com/articles/s41598-023-29049-2
Pseudorabies virus exploits N6-methyladenosine modification to promote viral replication
03/02/2023 - IntroductionPseudorabies virus (PRV) is the pathogenic virus of porcine pseudorabies (PR), belonging to the Herpesviridae family. PRV has a wide range of hosts and in recent years has also been...
Author Correction: Identification of MyoD-Responsive Transcripts Reveals a Novel Long Non-coding RNA (lncRNA-AK143003) that Negatively Regulates Myoblast Differentiation
03/02/2023 - Scientific Reports, Published online: 02 February 2023; doi:10.1038/s41598-023-28986-2Author Correction:...
Climacocystaceae fam. nov. and Gloeoporellaceae fam. nov., two new families of Polyporales (Basidiomycota)
03/02/2023 - Polyporales is a diverse group of Agaricomycetes including more than 2,500 species belonging to 255 genera and 18 families. Recently, many studies focused on the classification of Polyporales, but...
Estimation of cell lineages in tumors from spatial transcriptomics data
03/02/2023 - Nature Communications, Published online: 02 February 2023; doi:10.1038/s41467-023-36058-2Tau aggregates are...
Pulse-based cropping systems for soil health restoration, resources conservation, and nutritional and environmental security in rainfed agroecosystems
03/02/2023 - Pulses are an important source of energy and protein, essential amino acids, dietary fibers, minerals, and vitamins, and play a significant role in addressing global nutritional security. The...
Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer
03/02/2023 - Nature Communications, Published online: 02 February 2023; doi:10.1038/s41467-023-36258-wMeasuring proteomic...