Biotecnología
Biotecnología
Dicarbonyl-Modified Low-Density Lipoproteins Are Key Inducers of LOX-1 and NOX1 Gene Expression in the Cultured Human Umbilical Vein Endotheliocytes
02/01/2024 -
Abstract Expression of LOX-1 and NOX1 genes in the human umbilical vein endotheliocytes (HUVECs) cultured in the presence of low-density lipoproteins (LDL) modified with...
Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer’s Disease Signs Development
02/01/2024 -
Abstract GABA and glutamate are the most abundant neurotransmitters in the CNS and play a pivotal part in synaptic stability/plasticity. Glutamate and GABA homeostasis is...
Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease
02/01/2024 -
Abstract Alzheimer’s disease (AD) is the most common cause of dementia worldwide that has an increasing impact on aging societies. Besides its critical role in the control...
Opposite Effects of CRABP1 and CRABP2 Homologs on Proliferation of Breast Cancer Cells and Their Sensitivity to Retinoic Acid
02/01/2024 -
Abstract Resistance of tumor cells to retinoic acid (RA), a promising therapeutic agent, is the major factor limiting the use of RA in clinical practice. The mechanisms of...
Phenoptosis and the Various Types of Natural Selection
02/01/2024 -
Abstract In the first description of evolution, the fundamental mechanism is the natural selection favoring the individuals best suited for survival and reproduction...
Viral Vectors in Gene Replacement Therapy
02/01/2024 -
Abstract Throughout the years, several hundred million people with rare genetic disorders have been receiving only symptom management therapy. However, research and...
Phenoptosis. Preface to the Special Issue
02/01/2024
Role of Mitochondrial DNA in Yeast Replicative Aging
02/01/2024 -
Abstract Despite the diverse manifestations of aging across different species, some common aging features and underlying mechanisms are shared. In particular, mitochondria...
Changes in the Structure of Potato Virus A Virions after Limited in situ Proteolysis According to Tritium Labeling Data and Computer Simulation
02/01/2024 -
Abstract Coat proteins (CP) of the potato virus A virions (PVA) contain partially disordered N-terminal domains, which are necessary for performing vital functions of the...
The Role of Aurora B Kinase in Normal and Cancer Cells
02/01/2024 -
Abstract Aurora kinases are essential players in mammalian cell division. These kinases are involved in the regulation of spindle dynamics, microtubule–kinetochore...
Low-Frequency Oscillations of Bacteriochlorophyll Oligomers in Chlorosomes of Photosynthetic Green Bacteria
02/01/2024 -
Abstract In green photosynthetic bacteria, light is absorbed by bacteriochlorophyll (BChl) c/d/e oligomers, which are located in chlorosomes – unique structures created by...
Nocistatin and Products of Its Proteolysis Are Dual Modulators of Type 3 Acid-Sensing Ion Channels (ASIC3) with Algesic and Analgesic Properties
02/01/2024 -
Abstract The neuropeptide nocistatin (NS) is expressed by the nervous system cells and neutrophils as a part of a precursor protein and can undergo stepwise limited...
Topology of Ubiquitin Chains in the Chromatosomal Environment of the E3 Ubiquitin Ligase RNF168
02/01/2024 -
Abstract Genome stability is critical for normal functioning of cells, it depends on accuracy of DNA replication, chromosome segregation, and DNA repair. Cellular defense...
A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene
02/01/2024 -
Abstract Transcription factor NRF2 is involved in inflammatory reactions, maintenance of redox balance, metabolism of xenobiotics, and is of particular interest for studying...
The Role of Ubiquitin–Proteasome System in the Biology of Stem Cells
02/01/2024 -
Abstract Selective degradation of cellular proteins by the ubiquitin–proteasome system (UPS) is one of the key regulatory mechanisms in eukaryotic cells. A growing body of...
Effect of Dexamethasone on Adhesion of Human Neutrophils and Concomitant Secretion
02/01/2024 -
Abstract Neutrophils play a dual role in protecting the body. They are able to penetrate infected tissues and destroy pathogens there by releasing aggressive bactericidal...
Impact of Lipid Matrix Composition on Activity of Membranotropic Enzymes Galactonolactone Oxidase from Trypanosoma cruzi and L-Galactono-1,4-Lactone Dehydrogenase from Arabidopsis thaliana in the System of Reverse Micelles
02/01/2024 -
Abstract The study of many membrane enzymes in an aqueous medium is difficult due to the loss of their catalytic activity, which makes it necessary to use membrane-like...
Effects of Progesterone and Selective Ligands of Membrane Progesterone Receptors in HepG2 Cells of Human Hepatocellular Carcinoma
01/12/2023 -
Abstract Progesterone exerts multiple effects in different tissues through nuclear receptors (nPRs) and through membrane receptors (mPRs) of adiponectin and progestin...
“If I Were in Nature’s Place, I Would Do It Like This...” Life and Hypotheses of Alexey Olovnikov
01/12/2023 -
Abstract In this article, we commemorate the life and scientific journey of the brilliant gerontologist-theorist Alexey Olovnikov (1936-2022). In 1971, he published his famous...
Potential Geroprotectors – From Bench to Clinic
01/12/2023 -
Abstract Geroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve functioning of various...
Actuarial Aging Rates in Human Cohorts
01/12/2023 -
Abstract Aging rate is an important characteristic of human aging. Attempts to measure aging rates through the Gompertz slope parameter lead to a conclusion that actuarial...
