Biotecnología

Biotecnología

Lymphocyte Activation in the Development of Immune Tolerance in Women with Recurrent Pregnancy Loss
21/05/2020 - Abstract Association between lymphocyte activation and formation of immune tolerance, as well as pregnancy outcome, in the case of immunocytotherapy (ICT) was studied in women...
Protection of Cattle Elicited Using a Bivalent Lumpy Skin Disease Virus-Vectored Recombinant Rift Valley Fever Vaccine
21/05/2020 - Lumpy skin disease and Rift Valley fever are two high-priority livestock diseases which have the potential to spread into previously free regions through animal movement and/or vectors, as well as...
Melanin from the Lichens Cetraria islandica and Pseudevernia furfuracea : Structural Features and Physicochemical Properties
21/05/2020 - Abstract Lichens are symbiotic photosynthesizing organisms with thalli formed by fungi and algae/cyanobacteria that possess high stress tolerance. One of the factors that...
Immunogenicity of a DNA vaccine candidate for COVID-19
21/05/2020 - Nature Communications, Published online: 20 May 2020; doi:10.1038/s41467-020-15842-4Thalamic head direction...
The sprint to solve coronavirus protein structures — and disarm them with drugs
21/05/2020 - Nature, Published online: 15 May 2020; doi:10.1038/d41586-020-01487-2Breakneck triage nails many diagnoses, but...
Role of Arg243 and His239 Residues in the Recognition of Damaged Nucleotides by Human Uracil-DNA Glycosylase SMUG1
21/05/2020 - Abstract Human uracil-DNA glycosylase SMUG1 removes uracil residues and some other noncanonical or damaged bases from DNA. Despite the functional importance of this enzyme,...
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health [Developmental Biology]
21/05/2020 - Glassy polymers are extremely difficult to self-heal below their glass transition temperature (Tg) due to the frozen molecules. Here, we fabricate a series of randomly hyperbranched polymers (RHP)...
Insights Into the Role of Extracellular DNA and Extracellular Proteins in Biofilm Formation of Vibrio parahaemolyticus
21/05/2020 - The extracellular polymeric substances (EPS) construct the three-dimensional (3-D) structure of biofilms, but their respective roles are still not clear. Therefore, this study aimed to illuminate...
Immune Response and Protective Efficacy of Inactivated and Live Influenza Vaccines Against Homologous and Heterosubtypic Challenge
21/05/2020 - Abstract Inactivated (whole-virion, split, subunit, and adjuvanted) vaccines and live attenuated vaccine were tested in parallel to compare their immunogenicity and protective...
Tibetan PHD2, an allele with loss-of-function properties [Evolution]
21/05/2020 - Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding...
Epigenetic Regulation of Kaposi’s Sarcoma-Associated Herpesvirus Latency
21/05/2020 - Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic ?-herpesvirus that infects humans and exhibits a biphasic life cycle consisting of latent and lytic phases. Following entry into...
Two Glycosyl 1-Phosphate Polymers and Teichulosonic Acid from Glutamicibacter protophormiae VKM Ac-2104 T Cell Wall
21/05/2020 - Abstract Two glycosyl 1-phosphate polymers containing monoglycosyl 1-phosphate, -6)-?-D-Glcp-(1-P., and diglycosyl 1-phosphate, -6)-?-D-GalpNAc-(1?6)-?-D-GlcpNAc-(1-P., in the...
Combined loss of function of two different loci of miR-15/16 drives the pathogenesis of acute myeloid leukemia [Medical Sciences]
21/05/2020 - Split inteins are privileged molecular scaffolds for the chemical modification of proteins. Though efficient for in vitro applications, these polypeptide ligases have not been utilized for the...
Development of a Novel Lateral Flow Biosensor Combined With Aptamer-Based Isolation: Application for Rapid Detection of Grouper Nervous Necrosis Virus
21/05/2020 - Nervous necrosis virus (NNV) has infected more than 50 fish species worldwide, and has caused serious economic losses in the aquaculture industries. However, there is no effective antiviral...
?-Synuclein Overexpression in SH-SY5Y Human Neuroblastoma Cells Leads to the Accumulation of Thioflavin S-positive Aggregates and Impairment of Glycolysis
21/05/2020 - Abstract Deterioration of energy metabolism in affected cells is an important feature of synucleinopathies, including Parkinson's disease. Here, we studied the association...
CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis [Immunology and Inflammation]
21/05/2020 - Plant cuticles are composed of wax and cutin and evolved in the land plants as a hydrophobic boundary that reduces water loss from the plant epidermis. The expanding maize adult leaf displays a...
SMRT Sequencing of Paramecium Bursaria Chlorella Virus-1 Reveals Diverse Methylation Stability in Adenines Targeted by Restriction Modification Systems
21/05/2020 - Chloroviruses (family Phycodnaviridae) infect eukaryotic, freshwater, unicellular green algae. A unique feature of these viruses is an abundance of DNA methyltransferases, with isolates dedicating...
Mechanisms of Acinetobacter baumannii Capsular Polysaccharide Cleavage by Phage Depolymerases
21/05/2020 - Abstract Aerobic gram-negative bacterium Acinetobacter baumannii has recently become one of the most relevant pathogens associated with hospital-acquired infections worldwide....
Scaling of relaxation and excess entropy in plastically deformed amorphous solids [Applied Physical Sciences]
21/05/2020 - Meiosis generates a single-copy genome during two successive rounds of cell division after a single round of DNA replication. Failure to transmit exactly one copy of each chromosome during...
Allele-aware chromosome-level genome assembly and efficient transgene-free genome editing for the autotetraploid cultivated alfalfa
21/05/2020 - Nature Communications, Published online: 19 May 2020; doi:10.1038/s41467-020-16239-zChronic lung diseases are...
Molecular Targets in the Chemotherapy of Coronavirus Infection
21/05/2020 - Abstract In the pathogenesis of the infectious process in the respiratory tract by SARS, MERS, and COVID-19 coronaviruses, two stages can be distinguished: early (etiotropic)...