Biotecnología
Biotecnología
Pro-Inflammatory Activation Suppresses TRAIL-induced Apoptosis of Acute Myeloid Leukemia Cells
16/04/2024 -
Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising agent for treatment of AML due to its specific apoptosis-inducing effect on tumor...
The Impact of Long-Term Hypoxia on the Antioxidant Defense System in the Siberian Frog Rana amurensis
16/04/2024 -
Abstract The Siberian frog Rana amurensis has a uniquely high tolerance to hypoxia among amphibians, as it is able to withstand several months underwater with almost no oxygen...
Overexpression of the limk1 Gene in Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males
16/04/2024 -
Abstract Courtship suppression is a behavioral adaptation of the fruit fly. When majority of the females in a fly population are fertilized and non-receptive for mating, a...
Investigation of Potential Effects of Some Indole Compounds on the Glutathione S-Transferase Enzyme
16/04/2024 -
Abstract Glutathione S-transferases (GSTs) belong to the superfamily of multifunctional detoxification isoenzymes with an important role in cellular signaling. They can...
The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane
16/04/2024 -
Abstract Ionic liquids (ILs) are organic salts with a low melting point. This is due to the fact that their alkyl side chains, which are covalently connected to the ion,...
Erratum to: Viral Vectors in Gene Replacement Therapy
16/04/2024 -
In this article the funding section was misprinted unintentionally. The funding statement should be corrected as follows: A.D.E. was supported by the Russian Science...
Paired metagenomic and chemical evaluation of aflatoxin-contaminated dog kibble
16/04/2024 -
IntroductionIdentification of chemical toxins from complex or highly processed foods can present ‘needle in the haystack’ challenges for chemists. Metagenomic data can be used to guide chemical...
The Mechanism of Inhibition of Mycobacterial (p)ppGpp Synthetases by a Synthetic Analog of Erogorgiaene
16/04/2024 -
Abstract The synthesis of (p)ppGpp alarmones plays a vital role in the regulation of metabolism suppression, growth rate control, virulence, bacterial persistence, and biofilm...
Double-walled Al-based MOF with large microporous specific surface area for trace benzene adsorption
16/04/2024 -
Nature Communications, Published online: 13 April 2024; doi:10.1038/s41467-024-47615-8Maintaining a healthy...
Association of Increased Homocysteine Levels with Impaired Folate Metabolism and Vitamin B Deficiency in Early-Onset Multiple Sclerosis
16/04/2024 -
Abstract The contents of homocysteine (HCy), cyanocobalamin (vitamin B12), folic acid (vitamin B9), and pyridoxine (vitamin B6) were analyzed and the genotypes of the main...
Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data
16/04/2024 -
Abstract Some tricyclic antidepressants (TCAs), including amitriptyline (ATL), clomipramine (CLO), and desipramine (DES), are known to be effective for management of...
Novel Gain-of-Function Mutation in the Kv11.1 Channel Found in the Patient with Brugada Syndrome and Mild QTc Shortening
16/04/2024 -
Abstract Brugada syndrome (BrS) is an inherited disease characterized by right precordial ST-segment elevation in the right precordial leads on electrocardiograms (ECG), and...
Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration
16/04/2024 -
Abstract Structural organization of HIV-1 integrase is based on a tetramer formed by two protein dimers. Within this tetramer, the catalytic domain of one subunit of the first...
Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway
16/04/2024 -
Abstract Platelets are known for their indispensable role in hemostasis and thrombosis. However, alteration in platelet function due to oxidative stress is known to mediate...
Human Blood Serum Counteracts EGFR/HER2-Targeted Drug Lapatinib Impact on Squamous Carcinoma SK-BR-3 Cell Growth and Gene Expression
16/04/2024 -
Abstract Lapatinib is a targeted therapeutic inhibiting HER2 and EGFR proteins. It is used for the therapy of HER2-positive breast cancer, although not all the patients...
Protective Activity of Inactivated Rabies Vaccine Using Flagellin-Based Adjuvant
16/04/2024 -
Abstract Rabies is a zoonotic disease with high lethality. Most human deaths are associated with the bites received from dogs and cats. Vaccination is the most effective...
Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies
16/04/2024 -
Abstract Less than ten years ago, evidence began to accumulate about association between the changes in the composition of gut microbiota and development of human...
Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes
16/04/2024 -
Abstract Focal adhesions (FAs) are mechanosensory structures that transform physical stimuli into chemical signals guiding cell migration. Comprehensive studies postulate...
Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter
08/04/2024 -
Nature Communications, Published online: 06 April 2024; doi:10.1038/s41467-024-46807-6Identifying core...
Targeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method
08/04/2024 -
https://www.nature.com/articles/s41598-024-58733-0
Improved RNA stability estimation through Bayesian modeling reveals most Salmonella transcripts have subminute half-lives
08/04/2024 -
Proceedings of the National Academy of Sciences, Volume 121, Issue 14, April 2024.
