11/03/2024 -
Abstract The review considers the problem of hydrogen peroxide decomposition and hydroxyl radical formation in the presence of iron in vivo and in vitro. Analysis of the...
11/03/2024 -
Abstract Mutations that disrupt the function of the DNA/RNA-binding protein FUS could cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. One of...
11/03/2024 -
Abstract Data on the structure of G-quadruplexes, noncanonical nucleic acid forms, supporting an idea of their potential participation in regulation of gene expression in...
11/03/2024 -
Abstract The term “biomolecular condensates” is used to describe membraneless compartments in eukaryotic cells, accumulating proteins and nucleic acids. Biomolecular...
11/03/2024 -
Abstract This review highlights operational principles, features, and modern aspects of the development of third-generation sequencing technology of biopolymers focusing on...
11/03/2024 -
Abstract The strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling, identification of new...
11/03/2024 -
Abstract Neurodegenerative diseases are a growing global health problem with enormous consequences for individuals and society. The most common neurodegenerative diseases,...
11/03/2024 -
Abstract To date synthetic biology approaches involving creation of functional genetic modules are used in a wide range of organisms. In plants, such approaches are used both...
11/03/2024 -
Abstract The review discusses electrochemical methods for analysis of drug interactions with DNA. The electroanalysis method is based on the registration of...
11/03/2024 -
Abstract The review is devoted to the mechanisms of free radical lipid peroxidation (LPO) initiated by reactive halogen species (RHS) produced in mammals, including humans,...
11/03/2024 -
IntroductionSoil microorganisms play crucial roles in determining the fate of litter in desert steppes because their activities constitute a major component of the global carbon (C) cycle. Human...
11/03/2024 -
Abstract Reactive halogen species (RHS) are highly reactive compounds that are normally required for regulation of immune response, inflammatory reactions, enzyme function,...
11/03/2024 -
Abstract Precise quantification of human cells in preclinical animal models by a sensitive and specific approach is warranted. The probe-based quantitative PCR (qPCR) assay as a...
11/03/2024 -
Abstract Reactive oxygen species (ROS) are constantly generated in a living organism. An imbalance between the amount of generated reactive species in the body and their...
11/03/2024 -
Abstract Nucleic acids (NAs) are important components of living organisms responsible for the storage and transmission of hereditary information. They form complex structures...
11/03/2024 -
Abstract In many proteins, supplementary metal-binding centers appear under stress conditions. They are known as aberrant or atypical sites. Physico-chemical properties of...
04/03/2024 -
Abstract Intraventricular hemorrhage results in posthemorrhagic hydrocephalus (PHH). Neonatal hydrocephalus remains a challenging disease due to the high failure rate of all...
04/03/2024 -
Abstract Pursuing knowledge about circular RNA (circRNA), long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) expression profiles and their competing...
04/03/2024 -
Abstract Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved surveillance mechanism in eukaryotes primarily deployed to ensure RNA quality control by eliminating...