Biotecnología

Biotecnología

Fenton Reaction in vivo and in vitro. Possibilities and Limitations
11/03/2024 - Abstract The review considers the problem of hydrogen peroxide decomposition and hydroxyl radical formation in the presence of iron in vivo and in vitro. Analysis of the...
Animal Models of FUS-Proteinopathy: A Systematic Review
11/03/2024 - Abstract Mutations that disrupt the function of the DNA/RNA-binding protein FUS could cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. One of...
G-Quadruplexes as Sensors of Intracellular Na+/K+ Ratio: Potential Role in Regulation of Transcription and Translation
11/03/2024 - Abstract Data on the structure of G-quadruplexes, noncanonical nucleic acid forms, supporting an idea of their potential participation in regulation of gene expression in...
Biomolecular Condensates: Structure, Functions, Methods of Research
11/03/2024 - Abstract The term “biomolecular condensates” is used to describe membraneless compartments in eukaryotic cells, accumulating proteins and nucleic acids. Biomolecular...
Direct Determination of the Structure of Single Biopolymer Molecules Using Nanopore Sequencing
11/03/2024 - Abstract This review highlights operational principles, features, and modern aspects of the development of third-generation sequencing technology of biopolymers focusing on...
Tumor Organoids: The Era of Personalized Medicine
11/03/2024 - Abstract The strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling, identification of new...
The Role of Vitamin K in the Development of Neurodegenerative Diseases
11/03/2024 - Abstract Neurodegenerative diseases are a growing global health problem with enormous consequences for individuals and society. The most common neurodegenerative diseases,...
Synthetic Biology Approaches to Posttranslational Regulation in Plants
11/03/2024 - Abstract To date synthetic biology approaches involving creation of functional genetic modules are used in a wide range of organisms. In plants, such approaches are used both...
Electroanalysis in Pharmacogenomic Studies: Mechanisms of Drug Interaction with DNA
11/03/2024 - Abstract The review discusses electrochemical methods for analysis of drug interactions with DNA. The electroanalysis method is based on the registration of...
Free Radical Lipid Peroxidation Induced by Reactive Halogen Species
11/03/2024 - Abstract The review is devoted to the mechanisms of free radical lipid peroxidation (LPO) initiated by reactive halogen species (RHS) produced in mammals, including humans,...
Identification of bacteria and fungi responsible for litter decomposition in desert steppes via combined DNA stable isotope probing
11/03/2024 - IntroductionSoil microorganisms play crucial roles in determining the fate of litter in desert steppes because their activities constitute a major component of the global carbon (C) cycle. Human...
Reactive Halogen Species: Role in Living Systems and Current Research Approaches
11/03/2024 - Abstract Reactive halogen species (RHS) are highly reactive compounds that are normally required for regulation of immune response, inflammatory reactions, enzyme function,...
An Efficient Probe-Based Quantitative PCR Assay Targeting Human-Specific DNA in ST6GALNAC3 for the Quantification of Human Cells in Preclinical Animal Models
11/03/2024 - Abstract Precise quantification of human cells in preclinical animal models by a sensitive and specific approach is warranted. The probe-based quantitative PCR (qPCR) assay as a...
Post-Translational Oxidative Modifications of Hemostasis Proteins: Structure, Function, and Regulation
11/03/2024 - Abstract Reactive oxygen species (ROS) are constantly generated in a living organism. An imbalance between the amount of generated reactive species in the body and their...
Oldest stone tools in Europe hint at ancient humans’ route there
11/03/2024 - Nature, Published online: 06 March 2024; doi:10.1038/d41586-024-00575-xIn experiments dubbed the Random Genome...
Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects
11/03/2024 - Abstract Nucleic acids (NAs) are important components of living organisms responsible for the storage and transmission of hereditary information. They form complex structures...
Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions
11/03/2024 - Abstract In many proteins, supplementary metal-binding centers appear under stress conditions. They are known as aberrant or atypical sites. Physico-chemical properties of...
Long Noncoding RNA GAS5-Involved Progression of Neonatal Hydrocephalus and Inflammatory Responses
04/03/2024 - Abstract Intraventricular hemorrhage results in posthemorrhagic hydrocephalus (PHH). Neonatal hydrocephalus remains a challenging disease due to the high failure rate of all...
Comprehensive Analysis of circRNA, lncRNA, miRNA and mRNA Expression Profiles and Their Competing Endogenous RNA Networks in Hepatitis B Virus-Related Hepatocellular Carcinoma
04/03/2024 - Abstract Pursuing knowledge about circular RNA (circRNA), long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) expression profiles and their competing...
Messenger RNA Surveillance: Current Understanding, Regulatory Mechanisms, and Future Implications
04/03/2024 - Abstract Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved surveillance mechanism in eukaryotes primarily deployed to ensure RNA quality control by eliminating...